NAD+
Nicotinamide Adenine Dinucleotide
Recharge your cellular energy and slow the aging clock
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Quick Reference
| Peptide Class | Coenzyme / Longevity Compound |
| Half-Life | Varies by form; IV effects last 4-6 hours, subcutaneous 12-24 hours |
| Administration | IV infusion, Subcutaneous injection, Oral (NMN/NR precursors) |
| Typical Dosage | 250-500mg IV; 100-200mg subcutaneous |
| Cycle Length | Ongoing; monthly IV or weekly subcutaneous |
| Evidence Level | Moderate Preclinical / Emerging Human |
| Legal Status | Legal; available via telehealth prescription |
| Approximate Cost | $150-400/session IV; $80-150/month subcutaneous |
How NAD+ Works
Restores mitochondrial electron transport chain function and activates sirtuin longevity proteins
NAD+ fuels the mitochondrial electron transport chain, enabling ATP production. It also serves as a substrate for PARP enzymes (DNA repair) and sirtuins (epigenetic regulators of aging). Restoring NAD+ levels reactivates these pathways, improving cellular resilience and metabolic efficiency.
Evidence Base
Preclinical Evidence
Animal studies show lifespan extension and metabolic improvements with NAD+ precursor supplementation.
Human Evidence
Human trials demonstrate improved muscle function, cognitive performance, and metabolic markers.
Anecdotal Evidence
Users commonly report improved energy, mental clarity, and reduced fatigue within days of IV administration.
Key PubMed References:
Safety Profile
Side Effects
Generally well-tolerated. IV administration may cause flushing, nausea, or headache during infusion. Subcutaneous injection site reactions are mild and transient.
Contraindications
Active cancer (NAD+ may theoretically support tumor cell metabolism). Consult a physician before use if you have a history of malignancy.
PeptidePilot Assessment
NAD+ is PeptidePilot's top recommendation for users prioritizing energy, cognitive performance, and longevity simultaneously. It is the single compound with the broadest evidence base across all three of these domains and represents exceptional value for users over 40.
📊 18% of PeptidePilot users with energy and longevity as co-primary concerns receive NAD+ as their top match
Frequently Asked Questions
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