Glutathione
Glutathione (GSH)
The master antioxidant for cellular protection and radiant skin
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Quick Reference
| Peptide Class | Tripeptide / Master Antioxidant |
| Half-Life | Short; continuous synthesis required |
| Administration | IV infusion, Subcutaneous injection, Nebulized |
| Typical Dosage | 600-2400mg IV; 200-400mg subcutaneous |
| Cycle Length | Ongoing; weekly to monthly depending on protocol |
| Evidence Level | Moderate Preclinical / Emerging Human |
| Legal Status | Legal; available via telehealth prescription |
| Approximate Cost | $50-150/session IV; $60-120/month subcutaneous |
How Glutathione Works
Neutralizes free radicals, regenerates antioxidants, and supports liver detoxification pathways
Glutathione directly neutralizes reactive oxygen species and electrophiles. It conjugates with toxins in the liver (Phase II detoxification), regenerates oxidized antioxidants, and modulates immune cell function. IV and subcutaneous administration bypasses the poor oral bioavailability of glutathione, delivering it directly to tissues.
Evidence Base
Preclinical Evidence
Animal studies confirm antioxidant, hepatoprotective, and immune-modulating effects.
Human Evidence
Clinical trials show improved oxidative stress markers, liver enzymes, and skin pigmentation.
Anecdotal Evidence
Users report improved skin brightness, energy, and reduced post-illness recovery time.
Key PubMed References:
Safety Profile
Side Effects
Generally very well-tolerated. Rare: mild nausea, bloating with oral forms. IV administration is safe with proper protocols.
Contraindications
Chemotherapy patients should consult their oncologist — glutathione may theoretically reduce the efficacy of some chemotherapy agents.
PeptidePilot Assessment
Glutathione is PeptidePilot's top recommendation for users prioritizing skin health, detoxification, and immune support simultaneously. It is particularly well-suited for users who report high stress loads, frequent illness, or skin concerns alongside fatigue.
📊 7% of PeptidePilot users with skin and immune health as co-primary concerns receive Glutathione as their top match
Frequently Asked Questions
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