Low Dose Naltrexone (LDN)
Low Dose Naltrexone (LDN)
Calm inflammation and reset your immune system
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Quick Reference
| Peptide Class | Opioid Antagonist / Immunomodulator |
| Half-Life | 4-6 hours (but immunomodulatory effects persist) |
| Administration | Oral |
| Typical Dosage | 1.5-4.5mg at bedtime |
| Cycle Length | Ongoing; typically taken nightly |
| Evidence Level | Moderate Preclinical / Emerging Human |
| Legal Status | Prescription only; available via telehealth |
| Approximate Cost | $30-80/month via compounding pharmacy |
How Low Dose Naltrexone (LDN) Works
Transiently blocks opioid receptors to upregulate endorphins and modulate TLR4 immune signaling
At low doses, naltrexone briefly blocks opioid receptors, causing a compensatory upregulation of endogenous opioids (endorphins and enkephalins). It also directly modulates toll-like receptor 4 (TLR4) signaling on immune cells, reducing pro-inflammatory cytokine production. This dual mechanism makes it uniquely effective for inflammatory and autoimmune conditions.
Evidence Base
Preclinical Evidence
Animal models show anti-inflammatory, neuroprotective, and anti-tumor effects.
Human Evidence
Clinical trials confirm efficacy in Crohn's disease, fibromyalgia, MS, and CRPS.
Anecdotal Evidence
Users with autoimmune conditions report significant inflammation reduction and mood improvement within weeks.
Key PubMed References:
Safety Profile
Side Effects
Vivid dreams during the first 2-4 weeks (most common). Mild nausea at initiation. Both typically resolve with continued use.
Contraindications
Current opioid use (LDN will precipitate withdrawal). Pregnancy. Do not use within 7-10 days of opioid discontinuation.
PeptidePilot Assessment
LDN is PeptidePilot's top recommendation for users with chronic inflammation, autoimmune conditions, or mood disorders as primary concerns. Its exceptional safety profile and low cost make it one of the highest-value interventions available through telehealth.
📊 8% of PeptidePilot users with inflammation and mood as co-primary concerns receive LDN as their top match
Frequently Asked Questions
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