Rapamycin
Rapamycin (Sirolimus)
The most studied longevity drug — now available through telehealth
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Quick Reference
| Peptide Class | mTOR Inhibitor / Longevity Drug |
| Half-Life | 57-63 hours |
| Administration | Oral |
| Typical Dosage | 2-6mg once weekly (longevity protocol) |
| Cycle Length | Ongoing intermittent; typically once weekly |
| Evidence Level | Moderate Preclinical / Emerging Human |
| Legal Status | Prescription only; available via telehealth |
| Approximate Cost | $50-200/month depending on dose and pharmacy |
How Rapamycin Works
Inhibits mTORC1 to activate autophagy, reduce senescent cell accumulation, and rejuvenate immune function
Rapamycin inhibits mTORC1, a master regulator of cell growth and metabolism. mTORC1 inhibition activates autophagy (cellular cleanup), reduces senescent cell accumulation, rejuvenates immune function, and improves metabolic markers. The key insight is that intermittent low-dose use avoids the immunosuppressive effects seen at continuous high doses.
Evidence Base
Preclinical Evidence
Extends lifespan in yeast, worms, flies, and mice. Most replicated longevity intervention in animal models.
Human Evidence
Emerging data from longevity clinics shows immune rejuvenation and metabolic improvements. PEARL trial ongoing.
Anecdotal Evidence
Longevity clinic patients report improved energy, immune resilience, and metabolic markers.
Key PubMed References:
Safety Profile
Side Effects
At low intermittent doses: mouth sores (canker sores) in some users, mild immunosuppression. Metabolic effects (elevated lipids, insulin resistance) are dose-dependent and less common at longevity doses.
Contraindications
Active infection, pregnancy, known hypersensitivity. Use with caution in immunocompromised individuals. Requires physician supervision.
PeptidePilot Assessment
Rapamycin is PeptidePilot's top recommendation for users whose primary goal is longevity and who are willing to work with a physician on a monitored protocol. It has the strongest evidence base of any longevity compound and is increasingly accessible through telehealth platforms.
📊 6% of PeptidePilot users with longevity as their primary concern receive Rapamycin as their top match
Frequently Asked Questions
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